Nanoscopic medicine: the emergence of a new medical specialty


(Nanowerk News) A novel discipline is emerging in medicine: nanoscopic medicine. Nanoscopic medicine refers to the direct visualization, analysis (diagnosis) and modification (therapy) of nanoscopic protein machines in life cells and tissues with the

(I-Newswire) March 9, 2006 - (Nanowerk News) A novel discipline is emerging in medicine: nanoscopic medicine. Based on the premises that diseases manifest themselves as defects of cellular proteins, these proteins have been recently shown to form specific complexes exerting their functions as if they were nanoscopic machines. Nanoscopic medicine refers to the direct visualization, analysis (diagnosis) and modification (therapy) of nanoscopic protein machines in life cells and tissues with the aim to improve human health.
The term nanoscopic medicine was coined by a group of researchers in Germany whose mission is to extend live cell nanoscopy into a comprehensive diagnostic and therapeutic scheme. This includes both the creation of a set of novel instruments and the analysis of nanoscopic protein machine networks in health and disease. In addition, they seek to construct artificial devices mimicking cellular nanomachines.
Professor Reiner Peters and his team at the University of Münster (they also formed a separate spin-off company called Nascomed) in Germany told Nanowerk: "We are striving to a rapidly develop medical nanoscopy. However, the future implementation into medical praxis will depend on whether we succed in unifying all the parts of this new field, which are currently dissipated among disciplines such as genomics, proteomics, structural biology, systems biology, physical optics, photochemistry and medicine."
In two recent papers, the researchers introduce their concept. "Checking and fixing the cellular nanomachinery: towards medical nanoscopy" was published in the Feb. 2006 edition of Trends in Molecular Medicine and "Nanoscopic Medicine: The Next Frontier" was published in the March 1, 2006 online edition of small.
While nanoscopy refers to the visualization of structures on the nanometer scale, "medical nanoscopy" goes beyond diagnostics by including therapeutic applications as well.
"The target of nanoscopic medicine is that of traditional medicine, the diagnosis and therapy of the cell. However, the frontier is moved deep inside the cell towards its nanoscopic fundament" says Peters.
He explains an important distinction to nanotechnology: "Nanoscopic medicine must be clearly distinguished from applications of nanotechnology to medical questions, frequently referred to as nanomedicine. Nanoscopic medicine and nanomedicine represent opposing approaches. The roots of nanoscopic medicine lie in medicine while those of nanomedicine are found in nanotechnology."
He adds "Nanoscopic medicine seeks to analyze and improve the nanoscopic fundament of the cell while nanomedicine aims at the creation of artificial nanometer-sized devices such as particles, tubes, or sieves, if not electromechanical robots, for diagnostic and therapeutic purposes."
Nanoscopic Protein Machines (NPM)
Some protein complexes work as if they were nanometer-sized machines. NPM have clearly discernable parts, which move relative to each other during action, execute complex reactions in a specific order and frequently consume energy.
In living cells, protein complexes cooperate with each other to form functional modules - relatively autonomous 'assembly lines' arising from self assembly or positional assembly.
The emergence of the cell as a collection of protein machines has prompted attempts to create mathematical models able to mimic and predict cellular behavior. However, with a complex system such as the human cell, which involves ∼50,000-60 000 different proteins and an estimated 200,000 interactions, such an approach might be impractical. Instead, graph theory is used to construct networks in which the components are represented as nodes and their interactions as connections between nodes. However, the large number of parameters in such networks poses a mathematical challenge and current efforts are concentrating on simplifications.
Live Cell Imaging
The nanoscopic range first became accessible for fluorescence microscopy by single-molecule techniques (SFM - single-molecule fluorescence microscopy). Although single molecules are not resolved by these techniques, in living cells, localization accuracies of 20-30 nm have been obtained at a time resolution of a few milliseconds. A unprecedented increase in resolution, eventually breaking classical limits, was recently achieved by 4Pi microscopy and stimulated emission depletion (STED) microscopy.
In 4Pi microscopy, an object is positioned between two opposing objectives; the object is illuminated through these objectives by laser beams focused down to the diffraction limit. Fluorescence emitted from the focal spot is collected by both objectives and directed onto a sensitive photodetector. Images are obtained by scanning the object relative to the beam and by reconstructing an image from the point measurements. So far, a resolution of 30 nm has been obtained by combining STED with 4Pi microscopy.
Modification (Therapy) of NPM
Nanoscopic medicine is an emerging discipline that needs massive development before it can be incorporated into medical practice. Most of the fields involved are in an early state. A number of techniques for the quantitative analysis of molecular processes in microscopic systems have already been established. However, techniques such as fluorescence microphotolysis (fluorescence photobleaching), fluorescence correlation spectroscopy, and fluorescence resonance energy microscopy have yet to be adapted to the nanometer scale. Similarly, techniques for the photochemical and photomechanical manipulation of microscopic systems are available, but have yet to be adapted to the nanoscale.
By Michael Berger, Copyright 2006 Nanowerk LLC



Company Contact Information
Nanowerk News




Archive

March 9, 2006

If you have questions regarding information in this press release contact the company listed above. I-Newswire.com is a press release service and not the author of this press release. The information that is on or available through this site is for informational purposes only and speaks only as of the particular date or dates of that information. As some companies / PR Agencies submit their press releases once per week/month or quarter, make sure check the official company website for accurate release dates as our site displays the I-Newswire.com distribution date only. We do not guarantee the accuracy or completeness of information on or available through this site, and we are not responsible for inaccuracies or omissions in that information or for actions taken in reliance on that information.


Related Releases

Relish The Interesting Stories Of Amar Chitra Katha At Unbelievable Price On Infibeam

Get the best collection of Indian stories published by Amar Chitra Katha at infibeam, an online shopping website at an unbelievable additional 15% off.

Lamb of God Partners with Specticast for Worldwide Theatrical Distribution of "As The Palaces Burn" Documentary Film

As The Palaces Burn is a film about metal icons Lamb of God, the zealous passion of their fan base, and the gut-wrenching manslaughter trial of lead singer Randy Blythe.

Mervik Haums Publishes Free Infographic To Explain Affiliate Marketing

An Infographic is by far the best way to demonstrate any idea or marketing plan. As it is a visual representation of information, data and knowledge, the viewer get a very clear idea about whatever the graphic is built for.

86.7% Of People Think It Is A Good Time To Be Investing In Adelaide Property

Adelaide Finance Brokers Urbantech Group recently ran a survey on their website. They asked the simple question: "Do you think it is a good time to be i

The Metro Joins The Hunt For Santa With Ted Burns

Ted Burns, the host of Third Degree, is searching for Santa, also known as the Yuletide Yobbo. And now he's got the support of the Metro, the UK's leading free newspaper.

Latest 10 Headlines

$8 Million in Inventory Sold in 8 Weeks at 1200 The Ocean

This is the first oceanfront construction in Hillsboro Beach in over 10 years; it's on the only remaining available site of its kind in the area and there will be only 18 residences priced to $2 million+. Limited opportunities spur rapid sales.

GreenTech Ventures Joins Forces with eZ-Xpo to Launch Regional Innovation Network in West Virginia

eZ-Xpo in partnership with GreenTech Ventures aims to jumpstart local innovation and entrepreneurship in West Virginia with a business expo 2014, "Regional Innovation Cluster Network Ecosystem".

PULSE of NY to Offer Intensive Patient Safety Advocacy Training in May

Patient safety advocacy and education group PULSE of NY is to offer a course of intensive patient safety advocacy training on Long Island, aimed at preparing candidates for possible employment by a Long Island-based home care agency.

The Amazing Go Away

The Amazing Go Away can efficiently, quickly, and quietly remove disagreeable odors from the bathroom.

MBK Media Group Announces Availability of Luxury Business Cards

MBK Media Group is announcing immediate availability of Luxury Business Cards, enabling business owners that currently carry the standard business card to immediately upgrade their business card to a conversati

UNIFOSA Debuts Latest 12Gb/s SAS JBOD

High density 2U 24 bays with 2.5" HDD or SSD drives

Study BMV Approved Indiana Driver Safety Program on Smartphones and Tablets

Indiana Online Driver Improvement, Inc., a prominent provider of defensive driving courses in the state since 1996, offers a new, advanced mobile app to enable drivers in Indiana to conveniently study and complete a driver safety program.

A Space Place Storage

Groundbreaking Storage Company is now accepting Bitcoins, the universal digital currency

3 Reasons to Invest in a Mulberry Preschool Franchise

"The standing of a nation is how it attends to its children" UNICEF 2007.

TransFORM Introduces Häfele's New Engage Hardware Line from TAG to the New York Metro Area

transFORM, manufacturer of custom closets and built-in home storage, is proud to announce our premiere release of Häfele's new Engage hardware line from TAG in the New York Metro market. The Engage line is immediately available to our customers.

Helpful Articles

Increase Website Traffic By Using Press Releases
Write A Press Release For Big Time News
Get Backlinks From Press Releases
How To Write A Press Release Quick And Easy
Choosing A Press Release Service
Writing A News Press Release
Get More Traffic From Press Releases
Is A Press Release Service Worth It?
Effective Press Release Distribution
Create a Successful Online Press Release
Submit A Press Release and Get More Traffic
How To Write A Press Release
Check This Before You Send A Press Release
Using A Press Release Service For Your News Release

Our Services:

Submit Your Free Press Release Now.

Open Now:
Online Classified Ads at I-Newswire.com
Job Search Engine at I-Newswire.com
Car Search Engine at I-Newswire.com
Real Estate Search at I-Newswire.com
Website News Releases, Announcements and Updates

Other Cool Sites:
Breaking and Latest Automotive News
Learn the secrets on how to become an alpha male and how to meet girls on facebook at Dating-To-Mating.com. Check out the best spinner and instant article factory for your content writing needs.